Over-the-counter Orlistat Effective for Abdominal Obesity?

Published:June 26th, 2011

Over-the-counter Orlistat 60mg may be an effective self-treatment regimen for abdominal obesity in combination with low-calorie, low-fat diet even without the supervision of a health care professional, says a new study conducted by a group of scientists from Metabolic and Molecular Imaging Group, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, London and published in the June 2011 issue of the European Journal of Clinical Nutrition.

It is always been a common knowledge that having a low-calorie diet combined with the regular intake of weight loss drug orlistat results in a significantly greater weight reduction in the overweight and obese population. However, there is no documentation as to the effect of the over-the-counter orlistat to this particular population.

In this particular study, the researchers tried documenting the amount of adipose tissue reduced with regular intake of this OTC form of orlistat within the period of three months.They have found that there is a significant reduction in the amount of intra-abdominal adipose tissue content and fat surrounding the heart in patients who take OTC orlistat preparations. However, not only the adipose tissue content improved. There is also improvement in the blood lipid level, the blood pressure and the heart rate of the patients who used this medication.

Thus, the researchers of this study recommend the use of the over-the-counter orlistat 60mg in combination with low-calorie, low-fat diet to achieve healthy weight loss for it does not only improve the weight of the patients who use this particular medication but also the other parameters and risk factors for problematic metabolic diseases.

Orlistat is a pancreatic lipase inhibitor that effectively decreases the amount of fat absorbed by the intestines. The most common adverse events associated with this medication include increased flatulence, abdominal colic, oily stools and in some cases, stool incontinence. Nowadays, it is the only Food and Drug Administration-approved weight loss medication in the market.


European Journal of Clinical Nutrition; Pragmatic study of orlistat 60 mg on abdominal obesity; Thomas, E.L. et al.,; June 2011


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