Is Weight Loss Response to Gastric Bypass Inherited?

Published:September 6th, 2011

Some scientists are beginning to think that the weight loss response to gastric bypass may be an inherited trait, says a new study conducted at Gastrointestinal Metabolism Laboratory and Gastrointestinal Unit and Center for Human Genetic Research, Massachusetts General Hospital, Boston, and published in the August 2011 issue of the Journal of Clinical Endocrinology and Metabolism.

Gastric bypass is a very effective surgical method to induce weight loss in morbidly obese individuals. However, it is also an established fact that patients have individual response to gastric bypass and their weight loss varies widely because of unknown reasons. Because of this, a group of scientists begin looking into the possible contribution of genetic influences to the response of different groups of patients to the said surgical procedure.

In this particular study, the researchers tried mapping the genes of 848 patients who had gastric bypass surgery for their weight loss management. They were able to confirm the existence of some genes that may have some influence to the weight loss response to gastric bypass surgery. Thus, they have concluded that genetic factors may most likely play a role in the management of weight loss in patients who are having problems with losing weight. However, further clinical investigation is necessary to confirm this fact.

Reference:

Journal of Clinical Endocrinology and Metabolism; Heritability of the Weight Loss Response to Gastric Bypass Surgery; Hatoum, I.J. et al.; August 2011

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