Intranasal Insulin: A New Way of Increasing Post-meal Metabolism?

Published:March 9th, 2011

Intranasal insulin spray may enhance post-meal metabolism, according to a new study conducted in Department of Neuroendocrinology, University of Lübeck, Germany and published in the January 2011 issue of  the journal Diabetes. A number of animal studies suggest that the level of insulin in the brain can have a great effect in how the body manages energy expenditure after meals. In this clinical trial, the scientists aimed to prove the effect of this hormone in human subjects.

In this study, nineteen healthy males belonging to the age range of eighteen to twenty-six years old were recruited to receive 160 IU of intranasal insulin after an having some overnight fasting. Their blood sugar level, insulin level and free fatty acid concentration were measured before this intranasal administration of insulin, after they were given insulin and after taking in a 900 kcal liquid meal. The scientists found that compared to placebo, the subjects that received the intranasal insulin spray has a significantly greater energy expenditure post-meal compared to those who did not receive this hormone.

Thus, the scientists who performed this study concluded that the brain insulin level truly significantly increase the metabolic activity within the body. However, larger scale study is still necessary to establish their findings.

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